2'-O-(2-Methoxyethyl)cytidine

Product Name: 2'-O-(2-Methoxyethyl)cytidine
CAS No.: 223777-16-0
Chemical Name: 2'-O-(2-Methoxyethyl)cytidine
Synonyms: 2'-MOE-C;2'-MOE-rC;2'-O-MOE-rC;2'-O-MOE-Cr;2'-MOE-Cytidine;2'-O-MOE Cytidine;2'-O-MOE Cytidine;2'-O-(2-mthoxyethyl)Cytidine;2'-O-(2-Methoxyethyl)cytidine;2'-O-(2-Methoxyethyl)cytidine
CBNumber: CB32510559
Molecular Formula: C12H19N3O6
Formula Weight: 301.3
MOL File: 223777-16-0.mol

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2'-O-(2-Methoxyethyl)cytidine Property

Boiling point:: 535.3±60.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : 250 mg/mL (829.74 mM)
pka: 13.36±0.70(Predicted)
InChI: InChI=1S/C12H19N3O6/c1-19-4-5-20-10-9(17)7(6-16)21-11(10)15-3-2-8(13)14-12(15)18/h2-3,7,9-11,16-17H,4-6H2,1H3,(H2,13,14,18)/t7-,9-,10-,11-/m1/s1
InChIKey: YKOGMMXZKKVMBT-QCNRFFRDSA-N
SMILES: OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](OCCOC)[C@@H]1O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M262570
Product name: 2''-O-(2-Methoxyethyl)cytidine
Packaging: 25mg
Price: $1760
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0002420
Product name: 2'-O-(2-METHOXYETHYL)CYTIDINE
Purity: 95.00%
Packaging: 0.25G
Price: $786
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NM16315
Product name: 2'-O-(2-Methoxyethyl)cytidine
Packaging: 500mg
Price: $115
Updated: 2021/12/16

AK Scientific

Product number: 1312AB
Product name: 2'-O-(2-Methoxyethyl)-cytidine
Packaging: 1g
Price: $320
Updated: 2021/12/16

AK Scientific

Product number: 1312AB
Product name: 2'-O-(2-Methoxyethyl)-cytidine
Packaging: 2g
Price: $455
Updated: 2021/12/16

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2'-O-(2-Methoxyethyl)cytidine Chemical Properties,Usage,Production

Description

2'-O-(2-Methoxyethyl)-cytidine is a cytidine derivative that can be used as a building block for crosslinking oligonucleotides. 2'-O-(2-Methoxyethyl)-cytidine is also used as a texturizing agent in food products.

Uses

A cytidine derivative as building blocks for cross-linking oligonucleotides.

Synthesis

2'-O-(2-Methoxyethyl)uridine could be converted into the corresponding cytidine derivative (2'-O-(2-Methoxyethyl)cytidine) by the 4-nitrophenylation[1]. 2'-O-(2-Methoxyethyl)uridine, l-methylpyrrolidine, chlorotrimethylsilane and dry acetonitrile were stirred together at rt. After 1 h, the reaction mixture was cooled to 0 ℃, and trifluoroacetic anhydride was added dropwise over 5 min. After a further period of 30 rain at 0 ℃, 4-nitrophenol was added to the stirred reactants which were maintained at 0 °C. After 3 h, the products were poured into saturated aqueous sodium hydrogen carbonate, and the resulting mixture was extracted with dichloromethane. The combined organic layers were dried, and evaporated under reduced pressure. Concentrated aqueous ammonia was added to a stirred solution of the residue in dioxane, contained in a sealed flask that was then heated at 55°C for 24 h. The resulting yellow solution was concentrated under reduced pressure and the residue was evaporated with absolute ethanol. The products were fractionated by short column chromatography on silica gel and were evaporated under reduced pressure to give 2'-O-(2-Methoxyethyl)cytidine as an off-white solid.

References

[1] Urtzi et al. "Conversion of uridine into 2′-O-(2-methoxyethyl)uridine and 2′-O-(2-methoxyethyl)cytidine." Tetrahedron (1999).

2'-O-(2-Methoxyethyl)cytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-O-(2-Methoxyethyl)cytidine Suppliers

Canada 1 China 74 India 2 United Kingdom 1 United States 6 Global 84

Creative Peptides

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View Lastest Price from 2'-O-(2-Methoxyethyl)cytidine manufacturers

Yunbio Tech Co.,Ltd.

Product: 2'-O-(2-Methoxyethyl)cytidine 223777-16-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200KG per month
Release date: 2023-03-04

Zhejiang Hengkang Pharmaceutical Co., Ltd.

Product: 2'-O-(2-Methoxyethyl)cytidine 223777-16-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500kg per month
Release date: 2022-12-27

SHANGHAI NOVRIBO BIOTECH

Product: 2'-O-(2-methoxyethyl)-Cytidine；2’-MOE-C 223777-16-0
Price: US $100.00/kg
Min. Order: 0.009999999776482582kg
Purity: 99%
Supply Ability: 5tons
Release date: 2023-03-21

223777-16-0, 2'-O-(2-Methoxyethyl)cytidineRelated Search:

2'-O-Methylcytidine DMT-2μ-O-Me-rG(ib) amidite 2’-O-Methyl-rA(N-Bz)phosphoramidite DMT-2′Fluoro-dU Phosphoramidite 2'-O-MOE-A(Bz)-3'-phosphoramidite 2'-O-(2-Methoxyethyl)-5-methyluridine N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite N4-Benzoyl-5'-O-DMT-2'-O-methyl-5-methylcytidine 3'-CE phosphoramidite Dmt-2'-f-dc(ac) amidite 2'-O-Methyladenosine 2'-O-Methylguanosine 2'-O-(2-Methoxyethyl)uridine DMT-2'-O-MOE-rU Phosphoramidite 2'-O-MOE-ADENOSINE 2'-OMe-ibu-G Phosphoramidite 2'-O-(2-Methoxyethyl)guanosine

2'-O-(2-Methoxyethyl)cytidine

2'-O-MOE Cytidine

4-AMINO-1-[(2R,3R,4R,5R)-4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]PYRIMIDIN-2-ONE

2'-O-(2-Methoxyethyl)-cytidine, >97%

4-AMINO-1-[4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]PYRIMIDIN-2-ONE

4-amino-1-[(2R,3S,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]pyrimidin-2-one

Cytidine, 2'-O-(2-methoxyethyl)-

2'-O-MOE-rC

2'-MOE-Cytidine

2'-O-MOE-Cr

2'-MOE-rC

2'-MOE-C

4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl]pyrimidin-2-one

2'-O-(2-mthoxyethyl)Cytidine

2'-O-(2-Methoxyethyl)cytidine

2'-O-MOE Cytidine

223777-16-0

Bases & Related Reagents

Carbohydrates & Derivatives

Heterocycles

Nucleotides